Membrane-active peptides such as antimicrobial peptides (AMP) and cell-penetrating peptides (CPP) are routinely prepared in our lab by solid-phase peptide synthesis (SPPS) methodologies. These peptides are interesting from a therapeutic viewpoint, both per se as antimicrobials, or as "Trojan Horses" for intracellular delivery of other cargoes aimed at, for instance, gene therapy or translocation of antimalarials. Different projects in membrane-active peptides (MAP) are currently held in collaboration with many different research groups both in Portugal and abroad.