Peptide science Group @ UPorto

Full Publications List

  1. P. Gomes, E. Giralt, D. Andreu
    Surface plasmon resonance screening of synthetic peptides mimicking the immunodominant region of C-S8c1 foot-and-mouth disease virus.
    Vaccine, 18, 362-370 (1999).
    DOI: 10.1016/S0264-410X(99)00206-6

  2. P. Gomes, E. Giralt, D. Andreu
    Direct single-step surface plasmon resonance analysis of interactions between small peptides and immobilized monoclonal antibodies.
    Journal of     Immunological Methods 235, 101-111 (2000)..
    DOI: 10.1016/S0022-1759(99)00218-5

  3. W. F. Ochoa, S. Kalko, M. G. Mateu, P. Gomes, D. Andreu, E. Domingo, I. Fita, N. Verdaguer
    A multiply substituted GH loop from foot-and-mouth disease virus in complex with a neutralizing antibody: a role for water molecules.
    Journal of General Virology, 81, 1495-1505 (2000).
    DOI: 10.1099/0022-1317-81-6-1495    .

  4. E. Blanco, M. García-Briones, A. Sanz-Parra, P. Gomes, E. Oliveira, M. L. Valero, D. Andreu, V. Ley, F. Sobrino
    Identification of T-Cell Epitopes in Nonstructural Proteins of Foot-and-Mouth Disease Virus.
    Journal of Virology, 75, 3164-3174 (2001).
    DOI: 10.1128/JVI.75.7.3164-3174.2001    .

  5. P. Gomes, E. Giralt, D. Andreu
    Antigenicity modulation upon peptide cyclization: application to the GH loop of foot-and-mouth disease virus strain C1-Barcelona.
    Vaccine, 19, 3459-3466 (2001).
    DOI: 10.1016/S0264-410X(01)00047-0

  6. P. Gomes, E. Giralt, D. Andreu
    Molecular analysis of peptides from the GH loop of foot-and-mouth disease virus C-S30 using surface plasmon resonance: a role for kinetic rate constants.
    Molecular     Immunology, 37, 975-985 (2001)..
    DOI: 10.1016/s0161-5890(01)00014-1

  7. D. Pinho, P. Gomes, C. Freire, B. de Castro
    Ground State Modulation in Nickel(III) Chemistry by Controlling Axial Ligation in Complexes with N3O2 Pentadentate Ligands.
    European Journal of Inorganic Chemistry, 2001, 1483-1493 (2001).
    DOI: 10.1002/1099-0682(200106)2001:6<1483::AID-EJIC1483>3.0.CO;2-X

  8. P. Gomes, D. Andreu
    Direct kinetic assay of interactions between small peptides and immobilized antibodies using a surface plasmon resonance biosensor.
    Journal of Immunological Methods, 259, 217-230 (2002).
    DOI: 10.1016/S0022-1759(01)00503-8

  9. P. Gomes, E. Giralt, W. F. Ochoa, N. Verdaguer, D. Andreu
    Probing degeneracy in antigen-antibody recognition at the immunodominant site of foot-and-mouth disease virus.
    Journal of Peptide Research[1], 59, 221-231 (2002).
    DOI: 10.1034/j.1399-3011.2002.01959.x

  10. P. Gomes, M. I. Santos, M. J. Amaral-Trigo, R. Castanheiro, R. Moreira
    Improved synthesis of amino acid and dipeptide chloromethyl esters using bromochloromethane.
    Synthetic Communications, 33, 1683-1693 (2003).
    DOI: 10.1081/SCC-120018930

  11. P. Gomes, J. R. B. Gomes, M. Rodrigues, R. Moreira
    Amino acids as selective sulfonamide acylating agents.
    Tetrahedron, 59, 7473-7480 (2003).
    DOI: 10.1016/S0040-4020(03)01206-7

  12. E. Escribano-Romero, M. A. Jimenez-Clavero, P. Gomes, J. A. García-Ranea, V. Ley
    Heparan sulphate mediates swine vesicular disease virus attachment to the host cell.
    Journal of General Virology, 85, 653-663 (2004).
    DOI: 10.1099/vir.0.19603-0

  13. P. Gomes, M. J. Araújo, M. Rodrigues, N. Vale, Z. Azevedo, J. Iley, P. Chambel, J. Morais, R. Moreira
    Synthesis of imidazolidin-4-one and 1H-imidazo[2,1-a]isoindole-2,5(3H,9bH)-dione derivatives of primaquine: scope and limitations.
    Tetrahedron, 60, 5551-5562 (2004).
    DOI: 10.1016/j.tet.2004.04.077

  14. M. J. Araújo, J. Bom, R. Capela, C. Casimiro, P. Chambel, P. Gomes, J. Iley, F. Lopes, J. Morais, R. Moreira, E. de Oliveira, V. do Rosário, N. Vale
    Imidazolidin-4-ones of primaquine as novel transmission-blocking antimalarials.
    Journal of Medicinal Chemistry, 48, 888-892 (2005).
    DOI: 10.1021/jm0494624

  15. J. R. B. Gomes, P. Gomes
    Gas-phase acidity of sulfonamides: implications for reactivity and prodrug design.
    Tetrahedron, 61, 2705-2712 (2005).
    DOI: 10.1016/j.tet.2005.01.034

  16. C. Santos, M. L. Mateus, A. P. Santos, R. Moreira, E. de Oliveira, P. Gomes
    Cyclization-activated prodrugs.     Synthesis, reactivity and toxicity of dipeptide esters of paracetamol.
    Bioorganic and Medicinal Chemistry Letters, 15, 1595-1598 (2005).
    DOI: 10.1016/j.bmcl.2005.01.065

  17. J. R. B. Gomes, E. A. Sousa, J. M. Gonçalves, M. J. Monte, P. Gomes, S. Pandey, W. E. Acree, Jr., M. D. M. C. Ribeiro da Silva
    Energetics of the N-O bonds in 2-hydroxyphenazine-di-N-oxide .
    Journal of Physical Chemistry B, 109, 16188-16195 (2005).
    DOI: 10.1021/jp051350g

  18. F. Abrunhosa, S. Faria, P. Gomes, I. Thomaz, J. C. Pessoa, D. Andreu, M. Bastos
    Interaction and lipid-induced conformation of two cecropin-melittin hybrid peptides depends on peptide and membrane composition.
    Journal of Physical Chemistry B, 109, 17311-17319 (2005).
    DOI: 10.1021/jp051572e

  19. M. A. V. Ribeiro da Silva, J. I. T. A. Cabral, P. Gomes and J. R. B. Gomes
    Combined experimental and computational study of the thermochemistry of methylpiperidines.
    Journal of Organic Chemistry, 71, 3677-3685 (2006).
    DOI: 10.1021/jo052468w

  20. M. K. S. Batista, L. F. Pinto, C. A. R. Gomes, P. Gomes
    Novel highly-soluble peptide-chitosan polymers: chemical synthesis and spectral characterization.
    Carbohydrate Polymers, 64, 299-305 (2006).
    DOI: 10.1016/j.carbpol.2005.11.040

  21. H. D. Middendorf, N. Alves, J.-M. Zanotti, P. Gomes, M. Bastos
    Dynamics of an antibiotic oligopeptide.
    Physica B ? Condensed Matter, 385-386, 874-876 (2006).
    DOI: 10.1016/j.physb.2006.05.131

  22. R. O. Brito, E. F. Marques, P. Gomes, S. Falcão, O. Soderman
    Self-assembly in a catanionic mixture with an aminoacid-derived surfactant: from mixed micelles to spontaneous vesicles.
    Journal of Physical Chemistry B, 110, 18158-18165 (2006).
    DOI: 10.1021/jp061946j

  23. P. Chambel, R. Capela, F. Lopes, J. Iley, J. Morais, L. Gouveia, J. R. B. Gomes, P. Gomes, R. Moreira
    Reactivity of imidazolidin-4-one derivatives of primaquine: implications for prodrug design.
    Tetrahedron, 62, 9883-9891 (2006).
    DOI: 10.1016/j.tet.2006.08.026

  24. J. R. B. Gomes, E. A. Sousa, P. Gomes, N. Vale, J. M. Gonçlves, S. Pandey, W. E. Acree Jr., M. D. M. C. Ribeiro da Silva
    Thermochemical studies on 3-methyl-quinoxaline-2-carboxamide-1,4-dioxide derivatives: enthalpies of formation and of N-O bond dissociation.
    Journal of Physical Chemistry B, 111, 2075-2080 (2007).
    DOI: 10.1021/jp06818c

  25. J. R. B. Gomes, E. A. Sousa, J. M. Gonçlves, L. Gales, A. M. Damas, P. Gomes, S. Pandey, W. E. Acree Jr., M. D. M. C. Ribeiro da Silva
    Energetic and structural characterization of 2-R-3-methylquinoxaline-1,4-dioxides (R=benzoyl or tert-butoxycarbonyl): experimental and computational studies.
    Journal of Physical Organic Chemistry, 20, 491-498 (2007).
    DOI: 10.1002/poc.1184

  26. R. Ferraz, J. R. B. Gomes, E. de Oliveira, R. Moreira, P. Gomes
    Unanticipated stereoselectivity in the reaction of primaquine     a-aminoamides with substituted benzaldehydes: computational and experimental study.
    Journal of Organic Chemistry, 72, 4189-4197 (2007).
    DOI: 10.1021/jo0703202

  27. P. Gomes, N. Vale, R. Moreira
    Cyclization-activated prodrugs. (review)
    Molecules, 12, 2484-2506 (2007).
    DOI:10.3390/12112484

  28. P. Gomes, C. A. R. Gomes, M. Batista, L. F. Pinto, P. Silva
    Synthesis, structural characterization and properties of water-soluble N-(    g-propanoyl-amino acid)-chitosans.
    Carbohydrate Polymers, 71, 54-65 (2008).
    DOI: 10.1016/j.carbpol.2007.05.015

  29. N. Vale, M. S. Collins, J. Gut, R. Ferraz, P. J. Rosenthal, M. T. Cushion, R. Moreira, P. Gomes
    Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones.
    Bioorganic and Medicinal Chemistry Letters, 18, 485-488 (2008).
    DOI: 10.1016/j.bmcl.2007.11.105

  30. N. Vale, R. Moreira, P. Gomes
    Characterization of primaquine imidazolidin-4-ones with antimalarial activity by electrospray ionization-ion trap mass spectrometry.
    International Journal of Mass Spectrometry, 270, 81-93 (2008).
    DOI: 10.1016/j.ijms.2007.12.006

  31. M. Bastos, G. Bai, P. Gomes, D. Andreu, E. Goormaghtigh, M. Prieto
    Energetics and partition of two cecropin-melittin hybrid peptides to model membranes of different composition.
    Biophysical Journal, 94, 2128-2141 (2008).
    DOI: 10.1529/biophysj.107.119032

  32. P. D. Raposinho, C. Xavier, J. D. G. Correia, S. Falcão, P. Gomes, I. Santos
    Melanoma targeting with     a-melanocyte stimulating hormone analogs labeled with fac-[99mTc(CO)3]+: Effect of cyclization on tumor-seeking properties.
    Journal of Biological Inorganic Chemistry, 13, 449-459 (2008).
    DOI: 10.1007/s00775-007-0338-3

  33. R. Adão, R. Seixas, P. Gomes, J. Costa Pessoa, M. Bastos
    Membrane structure and interactions of a short Lycotoxin I analogue.
    Journal of Peptide Science, 14, 528-534 (2008).
    DOI: 10.1002/psc.993

  34. P. Gomes, M. J. Araújo, E. F. Marques, S. Falcão, R. O. Brito
    S    traightforward method for the preparation of lysine-based double-chained anionic surfactants.
    Synthetic Communications, 38, 2013-2024 (2008).
    DOI: 10.1080/00397910801997827

  35. C. Santos, J. Morais, L. Gouveia, E. de Clercq, C. Pannecouque, C. Nielsen, B. Steffansen, P. Gomes,
    Dipeptide derivatives of AZT: synthesis, chemical stability, activation in human plasma, hPEPT1 affinity and antiviral activity.
    ChemMedChem, 3, 970-978 (2008).
    DOI: 10.1002/cmdc.200800012

  36. N. Vale, J. Matos, J. Gut, F. Nogueira, V. do Rosário, P. Rosenthal, R. Moreira, P. Gomes
    Imidazolidin-4-one peptidomimetic derivatives of primaquine: synthesis and antimalarial activity.
    Bioorganic and Medicinal Chemistry Letters, 18, 4150-4153 (2008).
    DOI: 10.1016/j.bmcl.2008.05.076

  37. M. Valldosera, M. Monsò, C. Xavier, P. Raposinho, J. D. G. Correia, I. Santos, P. Gomes
    Comparative study of chemical approaches to the solid-phase synthesis of a tumor-seeking     a-MSH analogue.
    International Journal of Peptide Research and Therapeutics, 14, 273-281 (2008).
    DOI: 10.1007/s10989-008-9143-2

  38. N. Vale, J. Matos, R. Moreira, P. Gomes
    Electrospray ionization-ion trap mass spectrometry study of PQAAPro and PQProAA mimetic derivatives of the antimalarial primaquine.
    Journal of the American Society for Mass Spectrometry, 19, 1476-1490 (2008).
    DOI: 10.1016/j.jasms.2008.06.019

  39. E. F. Marques, R. O. Brito, S. Silva, M. L. Vale, J. E. Rodríguez-Borges, P. Gomes, M. J. Araújo, O. Soderman
    Spontaneous vesicles from catanionic mixtures of amino acid-based surfactants: chain symmetry effects.
    Langmuir, 24, 11009-11017 (2008).
    DOI: 10.1021/la801518h

  40. S. Trabulo, M. Mano, H. Faneca, A. L. Cardoso, S. Duarte, A. Henriques, A. Paiva, P. Gomes, S. Simões, M. C. Pedroso de Lima
    S413-PV cell penetrating peptide and cationic liposomes act synergistically for the intracellular delivery of plasmid DNA.
    Journal of Gene Medicine, 10, 1210-1222 (2008).
    DOI: 10.1002/jgm.1247

  41. N. Vale, J. Matos, R. Moreira, P. Gomes
    Amino acids as selective acylating agents: regiosselective N1-acylation of imidazolidin-4-one derivatives of the antimalarial drug primaquine.
    Tetrahedron, 64, 11144-11149 (2008).
    DOI: 10.1016/j.tet.2008.09.058

  42. R. O. Brito, E. F. Marques, P. Gomes, M. J. Araújo, R. Pons
    Structure/property relationships for the thermotropic behavior of lysine-based amphiphiles: from hexagonal to smectic phases.
    Journal of Physical Chemistry B, 112, 14877 (2008).
    DOI: 10.1021/jp8042494

  43. J. R. B. Gomes, A. R. Monteiro, B. B. Campos, P. Gomes, M. D. M. C. Ribeiro da Silva
    The enthalpies of dissociation of the N-O bonds in two quinoxaline derivatives.
    Journal of Physical Organic Chemistry, 22, 17-23 (2009).
    DOI: 10.1002/poc.1419

  44. N. Vale, R. Moreira, P. Gomes
    Primaquine revisited, six decades after its discovery. (invited review)
    European Journal of Medicinal Chemistry, 44, 937-953 (2009).
    DOI: 10.1016/j.ejmech.2008.08.011

  45. F. Marques, L. Gano, M. K. S. Batista, C. A. R. Gomes, P. Gomes, I. Santos
    Radiochemical and biological behaviour of 153Sm/166Ho-peptide-chitosan complexes.
    Journal of Labelled Compounds and Radiopharmaceuticals, 52, 79-83 (2009).
    DOI: 10.1002/jlcr.1571

  46. M. K. S. Batista, M. Gallemí, A. Adeva, C. A. R. Gomes, P. Gomes
    Facile regioselective synthesis of a novel chitosan-pexiganan conjugate with potential interest for the treatment of infected skin lesions.
    Synthetic Communications, 39, 1228-1240 (2009).
    DOI: 10.1080/00397910802517855

  47. C. Santos, R. Capela, C. Pereira, C. Pannecouque, E. de Clercq, R. Moreira, P. Gomes
    Structure-activity relationships for dipeptide prodrugs of acyclovir: implications for prodrug design.
    European Journal of Medicinal Chemistry, 44, 2339-2346 (2009).
    DOI: 10.1016/j.ejmech.2008.08.009

  48. N. Vale, L. Gouveia, R. Moreira, P. Gomes
    Primaquine dipeptide derivatives bearing an imidazolidin-4-one at the N-terminus as potential antimalarial prodrugs.
    European Journal of Medicinal Chemistry, 44, 2506-2516 (2009).
    DOI: 10.1016/j.ejmech.2009.01.018

  49. R. O. Brito, E. F. Marques, S. G. Silva, M. L. Vale, P. Gomes, M. J. Araújo, J. E. Rodríguez-Borges, M. R. Infante, M. T. Garcia, I. Ribosa, P. Vinardell, M. Mitjans
    Physicochemical and toxicological properties of novel amino acid-based amphiphiles and their spontaneously formed catanionic vesicles.
    Colloids and Surfaces B - Biointerfaces, 72, 80-87 (2009).
    DOI: 10.1016/j.colsurfb.2009.03.017

  50. N. Vale, J. Matos, R. Moreira, P. Gomes
    Electrospray ionization mass spectrometry as a valuable tool in the characterization of novel primaquine peptidomimetic derivatives.
    European Journal of Mass Spectrometry, 15, 627-640 (2009).
    DOI: 10.1255/ejms.1011

  51. N. Vale, M. Prudêncio, C. A. Marques, M. S. Collins, J. Gut, F. Nogueira, J. Matos, P. J. Rosenthal, M. T. Cushion, V. E. do Ros´rio, M. M. Mota, R. Moreira, P. Gomes
    Imidazoquines as antimalarial and anti-pneumocystis agents.
    Journal of Medicinal Chemistry, 52, 7800-7807 (2009).
    DOI: 10.1021/jm900738c

  52. I. Fernandes, N. Vale, V. de Freitas, R. Moreira, N. Mateus, P. Gomes
    Anti-tumoral activity of imidazoquines, a new class of antimalarials derived from primaquine.
    Bioorganic and Medicinal Chemistry Letters, 19, 6914-6917 (2009).
    DOI: 10.1016/j.bmcl.2009.10.081

  53. J. Matos, N. Vale, M. S. Collins, J. Gut, P. J. Rosenthal, M. T. Cushion, R. Moreira, P. Gomes
    PRIMACENES: novel non-cytotoxic primaquine-ferrocene conjugates with anti-Pneumocystis carinii activity.
    MedChemComm, 1, 199-201 (2010).
    DOI: 10.1039/C0MD00082E

  54. M. C. Botelho, R. Soares, N. Vale, R. Ribeiro, V. Camilo, R. Almeida, R. Medeiros, P. Gomes, J. C. Machado, J. M. Correia da Costa
    Schistosoma haematobium: Identification of new estrogenic molecules with estradiol antagonistic activity and ability to inactivate Estrogen Receptor in mammalian cells.
    Experimental Parasitology, 126, 526-535 (2010).
    DOI: 10.1016/j.exppara.2010.06.012

  55. J. Cortez, E. Vorobieva, I. Osório, L. Soares, N. Vale, E. Pereira,P. Gomes, R. Franco
    Bionanoconjugates of tyrosinase and peptide-derivatised gold nanoparticles for biosensing of phenolic compounds.
    Journal of Nanoparticle Research, 13, 1101-1113 (2011).
    DOI: 10.1007/s11051-010-0099-8

  56. M. C. L. Martins, F. Costa, I. F. Carvalho, R. C. Montelaro, P.Gomes
    Antimicrobial Peptides (AMP) covalently immobilized onto biomaterial surfaces.
    Acta Biomaterialia, 7, 1431-1440 (2011).
    DOI: 10.1016/j.actbio.2010.11.005
    This article was selected by the journal's Editor-in-Chief as one of the 6 best articles of 2011.

  57. C. Teixeira, J. R. B. Gomes, F. Barbault, P. Gomes, F. Maurel
    HIV-1 surface glycoproteins as potential drug targets against AIDS: a brief overview one quarter of a century past the approval of zidovudine, the first anti-retroviral drug.

    European Journal of Medicinal Chemistry, 46, 979-992 (2011).
    DOI:10.1016/j.ejmech.2011.01.046
    This article ranked 2nd in the 25 hottest articles of the European Journal of Medicinal Chemistry in 2011

  58. C. Teixeira, J. R. B. Gomes, P. Gomes

    Falcipains, Plasmodium falciparum cysteine proteases as key drug targets against malaria.
    Current Medicinal Chemistry, 18, 1555-1572 (2011).
    DOI:10.2174/092986711795328328

  59. C. Teixeira, J. R. B. Gomes, T. Cuesnon, P. Gomes

    Molecular docking and 3D-Quantitative Structure Activity Relationship analyses of peptidyl vinyl sulfones, Plasmodium Falciparum cysteine proteases inhibitors.
    Journal of Computer-Aided Molecular Design, 25, 763-775 (2011).
    DOI:10.1007/s10822-011-9459-4

  60. J. R. R. Oliveira, L. Mafra, M. C. Martins, P. Gomes

    Synthesis of an O-alkynyl-chitosan and its chemoselective conjugation with a PEG-like amino-azide through click chemistry.
    Carbohydrate Polymers, 87, 240-249 (2012).
    DOI:10.1016/j.carbpol.2011.07.043

  61. M. L. F. Viveiros, V. Freitas, N. Vale, P. Gomes, M. D. M. C. Ribeiro da Silva

    Molecular energetics of quinoxaline N-oxide derivatives. The dissociation enthalpies of the N-O bonds.
    Journal of Physical Organic Chemistry, 25, 420-426 (2012).
    DOI:10.1002/poc.1932

  62. T. Morais, M. E. Soares, J. A. Duarte, L. Soares, S. Maia, P. Gomes, E. Pereira, S. Fraga, H. Carmo, M. L. Bastos

    Effect of surface coating on the biodistribution profile of gold nanoparticles in the rat.
    European Journal of Pharmaceutics and Biopharmaceutics, 80, 185-193 (2012).
    DOI:10.1016/j.ejpb.2011.09.005

  63. J. Matos, F. P. da Cruz, E. Cabrita, J. Gut, F. Nogueira, V. do Rosário, P. J. Rosenthal, R. Moreira, M. Prudêncio, P. Gomes

    Novel potent metallocenes against liver-stage malaria.
    Antimicrobial Agents and Chemotherapy, 56, 1564-1570 (2012).
    DOI:10.1128/AAC.05345-11

  64. A. M. Cardoso, S. Trabulo, A. L. Cardoso, A. Lorents, C. M. Morais, P. Gomes, C. Nunes, M. Lúcio, S. Reis, K. Padari, M. Pooga, M. C. Pedroso de Lima, M. A. Jurado

    S4(13)-PV cell-penetrating peptide induces physical and morphological changes in membrane mimetic lipid systems and cell membranes: implications for cell internalization and endosomal escape.
    Biochimica et Biophysica Acta - Biomembranes, 1818, 877-888 (2012).
    DOI:10.1016/j.bbamem.2011.12.022

  65. N. Vale, I. Fernandes, R. Moreira, N. Mateus, P. Gomes

    Comparative analysis of in vitro rat liver metabolism of the antimalarial primaquine and a derived imidazoquine.
    Drug Metabolism Letters, 6, 15-25 (2012).
    DOI:10.2174/187231212800229273

  66. N. Vale, E. Makila, J. Salonen, P. Gomes, J. Hirvonen, H. A. Santos

    New times, new trends for ethionamide: in vitro evaluation of drug-loaded thermally carbonized porous silicon microparticles.
    European Journal of Pharmaceutics and Biopharmaceutics, 81, 314-323 (2012).
    DOI:10.1016/j.ejpb.2012.02.017

  67. B. Pérez, C. Teixeira, M. Figueiras, J. Gut. P. J. Rosenthal, J. R. B. Gomes, P. Gomes
    Novel cinnamic acid/4-aminoquinoline conjugates bearing non-proteinogenic amino acids: towards the development of potential dual-action antimalarials.

    European Journal of Medicinal Chemistry, 54, 887-899 (2012).
    DOI:10.1016/j.ejmech.2012.05.022

  68. B. Pérez, C. Teixeira, J. Gut. P. J. Rosenthal, J. R. B. Gomes, P. Gomes

    New cinnamic acid/chloroquinoline conjugates as potent agents against chloroquine-resistant Plasmodium falciparum malaria parasites.
    ChemMedChem, 7, 1537-1540 (2012).
    DOI:10.1002/cmdc.201200257
    This work was highlighed in the back cover of the ChemMedChem Sept2012 issue

  69. B. Pérez, C. Teixeira, I. S. Albuquerque, J. Gut. P. J. Rosenthal, M. Prudêncio, P. Gomes

    PRIMACINS, N-cinnamoyl-primaquine conjugates with improved liver-stage antimalarial activity.
    MedChemComm, 3, 1170-1172 (2012).
    DOI:10.1039/C2MD20113E
    The relevance of this work was highlighted in the Royal Society of Chemistry bulletin "Chemistry World"

  70. S. Vale-Costa, N. Vale, A. Tomás, R. Moreira, P. Gomes, M. S. Gomes

    Evaluation of dipeptide and peptidomimetic derivatives of primaquine against Leishmania infantum.
    Antimicrobial Agents and Chemotherapy, 56, 5774-5781 (2012).
    DOI:10.1128/AAC.00873-12

  71. B. Pérez, C. Teixeira, J. R. B. Gomes, P. Gomes
    Development of Plasmodium falciparum protease inhibitors in the past decade (2002-2012).
    Current Medicinal Chemistry, 20, 3049-3068 (2013).
    DOI: 10.2174/0929867311320250003

  72. A. L. Silva, A. Cimas, N. Vale, P. Gomes, M. J. S. Monte, M. D. M. C. Ribeiro da Silva

    Experimental and computational study of the energetics of hydantoin and 2-thiohydantoin.
    Journal of Chemical Thermodynamics, 58, 158-165 (2013).
    DOI:10.1016/j.jct.2012.10.010

  73. N. Vale, P. Gomes, H. A. Santos
    Metabolism of the antituberculosis drug ethionamide.
    Current Drug Metabolism, 14, 151-158 (2013).
    DOI:10.2174/138920013804545151

  74. S. I. Falcão, N. Vale, P. Gomes, M. R. M. Domingues, C. Freire, S. M. Cardoso, M. Vilas-Boas
    Phenolic profiling of Portuguese propolis by LC/MS spectrometry: uncommon propolis rich in flavonoid glycosides.
    Phytochemical Analysis, 24, 309-318 (2013).
    DOI: 10.1002/pca.2412

  75. B. Pérez, C. Teixeira, I. S. Albuquerque, J. Gut. P. J. Rosenthal, J. R. B. Gomes, M. Prudêncio, P. Gomes
    N-cinnamoylated chloroquine analogues as dual-stage antimalarial leads.
    Journal of Medicinal Chemistry, 56, 556-567 (2013).
    DOI:10.1021/jm301654b

  76. B. Pérez, C. Teixeira, A. Gomes, I. S. Albuquerque, J. Gut. P. J. Rosenthal, M. Prudêncio, P. Gomes
    In vitro efficiency of 9-(N-cinnamoylbutyl)aminoacridines against blood- and liver-stage malaria parasites.
    Bioorganic and Medicinal Chemistry Letters, 23, 610-613 (2013).
    DOI:10.1016/j.bmcl.2012.12.032

  77. M. C. Botelho, N. Vale, M. J. Gouveia, G. Rinaldi, J. Santos, L. L. Santos, P. Gomes, P. J. Brindley, J. M. Correia da Costa
    Tumour-like phenotypes in urothelial cells after exposure to antigens from eggs of Schistosoma haemotobium: an oestrogen-DNA adducts mediated pathway?
    International Journal for Parasitology, 43, 17-26 (2013).
    DOI:10.1016/j.ijpara.2012.10.023

  78. M. J. Gouveia, P. J. Brindley, L. L. Santos, J. M. Correia da Costa, P. Gomes, N. Vale
    Mass spectrometry techniques in the survey of steroid metabolites as potential disease biomarkers: a review.
    Metabolism, 62, 1206-1217 (2013).
    DOI:10.1016/j.metabol.2013.04.003

  79. S. I. Falcão, N. Vale, P. Cos, P. Gomes, C. Freire, L. Maes, M. Vilas-Boas
    Evaluation of Portuguese propolis and floral sources for inhibitory activity against pathogenic protozoa.
    Phytotherapy Research, 28, 437-443 (2014).
    DOI:10.1002/ptr.5013

  80. S. Vale-Costa, J. Gouveia, B. Pérez, T. Silva, C. Teixeira, P. Gomes, M. S. Gomes
    N-cinnamoylated aminoquinolines as promising anti-leishmanial agents.
    Antimicrobial Agents and Chemotherapy, 57, 5112-5115 (2013).
    DOI:10.1128/AAC.00557-13

  81. A. M. Cardoso, S. Trabulo, A. L. Cardoso, S. Maia, P. Gomes, A. S. Jurado, M. C. Pedroso de Lima
    Comparison of the efficiency of complexes based on S413-PV cell-penetrating peptides in plasmid DNA and siRNA delivery.
    Molecular Pharmaceutics, 10, 2653-2666 (2013).
    DOI:10.1021/mp400078h

  82. S. I. Falcão, N. Vale, P. Gomes, M. R. M. Domingues, C. Freire, S. M. Cardoso, M. Vilas-Boas
    Phenolic quantification and botanical origin of Portuguese propolis.
    Industrial Crops and Products, 49, 805-812 (2013).
    DOI:10.1016/j.indcrop.2013.07.021

  83. M. Bastos, L. Alves, S. Maia, P. Gomes, A. Inaba, Y. Miyazaki, J.-M. Zanotti
    Hydration water and peptide dynamics - two sides of a coin. A neutron scattering and adiabatic calorimetry study at low hydration and cryogenic temperatures.
    Physical Chemistry Chemical Physics, 15, 16693-16703 (2013).
    DOI:10.1039/c3cp51937f

  84. N. Vale, M. J. Gouveia, M. Botelho, B. Sripa, S. Suttiprapa, G. Rinaldi, P. Gomes, P. J. Brindley, J. M. Correia da Costa
    Carcinogenic liver fluke Opistorchis viverrini oxysterols detected by LC-MS/MS survey of soluble fraction parasite extract.
    Parasitology International, 62, 535-542 (2013).
    DOI:10.1016/j.parint.2013.08.001

  85. P. Kadhirvel, M. A. G. O. Azenha, S. Shinde, E. Schillinger, P. Gomes, B. Sellergren, F. Silva
    Imidazolium-based functional monomers for the imprinting of the anti-inflammatory drug naproxen: Comparison of acrylic and sol-gel procedures.
    Journal of Chromatography A, 1314, 115-123 (2013).
    DOI:10.1016/j.chroma.2013.09.015

  86. B. C. Pérez, I. Fernandes, N. Mateus, C. Teixeira, P. Gomes
    Recycling antimalarial leads for cancer: antiproliferative properties of N-cinnamoyl chloroquine analogues.
    Bioorganic and Medicinal Chemistry Letters, 23, 6769-6772 (2013).
    DOI:10.1016/j.bmcl.2013.10.025

  87. B. C. Pérez, S. Antunes, L. Gonçalves, A. Domingos, J. R. B. Gomes, P. Gomes, C. Teixeira
    Toward the discovery of inhibitors of babesipain-1, a Babesia bigemina cysteine protease: in vitro evaluation, homology modeling and molecular docking studies.
    Journal of Computer-Aided Molecular Design, 27, 823-835 (2013).
    DOI:10.1007/s10822-013-9682-2

  88. M. C. L. Martins, S. Freitas, S. Maia, A. C. Figueiredo, P. Gomes, P. J. B. Pereira, M. A. Barbosa
    Selective albumin-binding surfaces modified with a thrombin-inhibiting peptide.
    Acta Biomaterialia, 10, 1227-1237 (2014).
    DOI:10.1016/j.actbio.2013.11.023

  89. J. R. B. Gomes, M. Jorge, P. Gomes
    Interaction of chitosan and chitin with Ni, Cu and Zn ions: a computational study.
    Journal of Chemical Thermodynamics, 73, 121-129 (2014).
    DOI:10.1016/j.jct.2013.11.016

  90. A. Gomes, B. Pérez, I. Albuquerque, M. Machado, F. Nogueira, M. Prudêncio, C. Teixeira, P. Gomes
    N-cinnamoylation of antimalarial classics: new quinacrine analogues with reduced toxicity and dual-stage activity.
    ChemMedChem, 9, 305-310 (2014).
    DOI:10.1002/cmdc.201300459

  91. F. Costa, S. Maia, J. Gomes, P. Gomes, M. C. L. Martins
    Characterization of hLF1-11 immobilization onto chitosan ultrathin films, and its effects on antimicrobial activity.
    Acta Biomaterialia, 10, 3513-3521 (2014).
    DOI: 10.1016/j.actbio.2014.02.028

  92. T. Silva, B. Magalhães, S. Maia, P. Gomes, K. Nazmi, J. G. M. Bolscher, P. N. Rodrigues, M. Bastos, M. S. Gomes
    Killing of Mycobacterium avium by lactoferricin peptides: improved activity of arginine- and D-amino acids-containing peptides.
    Antimicrobial Agents and Chemotherapy, 58, 3461-3467 (2014).
    DOI: 10.1128/AAC.02728-13

  93. J. Santos, M. J. Gouveia, N. Vale, M. L. Delgado, A. Gonçalves, J. M. Teixeira da Silva, C. Oliveira, P. Xavier, P. Gomes, L. L. Santos, C. Lopes, A. Barros, G. Rinaldi, P. J. Brindley, J. M. Correia da Costa, M. Sousa, M. C. Botelho
    Urinary estrogen metabolites and self-reported infertility in women infected with Schistosoma haematobium.
    PLoS ONE, 9, e96774 (2014).
    DOI: 10.1371/journal.pone.0096774

  94. R. Maia, M. Barbosa, D. B. Gomes, P. Gomes, P. L. Granja, C. C. Barrias
    Hydrogel depots for local co-delivery of osteoinductive peptides and mesenchymal stem cells.
    Journal of Controlled Release, 189, 158-168 (2014).
    DOI: 10.1016/j.jconrel.2014.06.030

  95. C. Teixeira, N. Vale, Pérez, A. Gomes, J. R. B. Gomes, P. Gomes Recycling classical drugs for malaria.
    Chemical Reviews, 114, 11164-11220 (2014).
    DOI: 10.1021/cr500123g

  96. N. Vale, L. Aguiar, P. Gomes
    Antimicrobial peptides: a new class of antimalarial drugs?
    Frontiers in Pharmacology - Experimental pharmacology and Drug Design, 5, 275 (2014).
    DOI: 10.3389/fphar.2014.00275

  97. C. Monteiro, M. Fernandes, M. Pinheiro, S. Maia, C. L. Seabra, F. F. Silva, F. Costa, S. Reis, P. Gomes, M. C. L. Martins
    Antimicrobial properties of membrane-active dodecapeptides derived from MSI-78.
    Biochimica et Biophysica Acta - Biomembranes, 1848, 1139-1146 (2015).
    DOI: 10.1016/j.bbamem.2015.02.001

  98. F. Costa, S. Maia, P. Gomes, M. C. L. Martins
    Dhvar5 antimicrobial peptide (AMP) chemoselective covalent immobilization results on higher antiadherence effect than simple physical adsorption.
    Biomaterials, 52, 531-538 (2015).
    DOI: 10.1016/j.biomaterials.2015.02.049

  99. C. Monteiro, M. Pinheiro, M. Fernandes, S. Maia, C. L. Seabra, F. F. Silva, S. Reis, P. Gomes, M. C. L. Martins
    A 17-mer membrane-active MSI-78 derivative with improved selectivity towards bacterial cells.
    Molecular Pharmaceutics, 12, 2904-2911 (2015).
    DOI: 10.1021/acs.molpharmaceut.5b00113

  100. R. Ferrer-Gallego, N. Quijada-Morína, N. F. Brás, P. Gomes, V. de Freitas, J. C. Rivas-Gonzalo, M. Teresa Escribano-Bailón
    Characterization of sensory properties of flavanols. A molecular dynamics approach.
    Chemical Senses, 40, 381-390 (2015).
    DOI: 10.1093/chemse/bjv018

  101. A. Gomes, M. Machado, L. Lobo, F. Nogueira, M. Prudêncio, C. Teixeira, P. Gomes
    N-cinnamoylation of antimalarial classics: effects of using acyl groups other than cinnamoyl towards dual-stage antimalarials.
    ChemMedChem, 10, 1344-1349 (2015).
    DOI: 10.1002/cmdc.201500164

  102. M. Barbosa, M. Cristina L. Martins, P. Gomes
    Grafting techniques towards production of peptide-tethered hydrogels, a novel class of materials with biomedical interest.
    Gels, 1, 194-218 (2015).
    DOI: 10.3390/gels1020194

  103. P. Kadhirvel, M. Azenha, P. Gomes, A. F. Silva, B. Sellergren
    Aminoglutethimide-imprinted xerogels in bulk and spherical formats, based on a multifunctional organo-alkoxysilane precursor.
    Journal of Chromatography A, 1424, 59-68 (2015).
    DOI: 10.1016/j.chroma.2015.10.097

  104. N. Vale, R. C. Veloso, P. Gomes
    Exploring the solid-phase synthesis of sulfotyrosine peptides.
    European Journal of Organic Chemistry, 2015, 7413-7425 (2015).
    DOI: 10.1002/ejoc.201500715

  105. M. Barbosa, M. C. L. Martins, P. Gomes
    "Click" chemistry as a tool to create novel biomaterials: a short review.
    U.Porto Journal of Engineering, 1, 22-34 (2018).
    DOI: 10.24840/2183-6493_001.001_0004

  106. C. Teixeira, F. Barbault, T. Couesnon, J. R. B. Gomes, P. Gomes, F. Maurel
    Striking HIV-1 entry by targeting HIV-1 gp41. But, where should we target?
    PLoS ONE, 11, e0146743 (2016).
    DOI: 10.1371/journal.pone.0146743

  107. I. C. Gonçalves, A. Magalhães, A. M. S. Costa, J. R. Oliveira, P. C. Henriques, P. Gomes, C. Reis, M. Cristina L. Martins.
    Bacteria-targeted biomaterials: glycan-coated microspheres to bind Helicobacter pylori
    Acta Biomaterialia, 33, 40-50 (2016).
    DOI: 10.1016/j.actbio.2016.01.029

  108. M. E. Sousa, M. J. Araújo, M. L. do Vale, P. Andrade, P. Branco, P. Gomes, R. Moreira, T. M. V. D. Pinho e Melo, V. Freitas.
    11th National Meeting of Organic Chemistry and 4th Meeting of Therapeutic Chemistry - Meeting Report
    Pharmaceuticals, 9, 15 (2016).
    DOI: 10.3390/ph9010015

  109. R. Ferraz, J. Noronha, F. Murtinheira, F. Nogueira, M. Machado, M. Prudêncio, S. Parapini, S. D'Alessandro, C. Teixeira, A. Gomes, C. Prudêncio, P. Gomes
    Primaquine-based ionic liquids as a novel class of antimalarial hits
    RSC Advances, 6, 56134-56138 (2016).
    DOI: 10.1039/C6RA10759A

  110. J. R. Almeida L. M. Resende, R. K. Watanabe, V. C. Corassola, S. Huancahuire-Vega, C. A. da S. Caldeira, A. Coutinho-Neto, A. M. Soares, N. Vale, P. Gomes, S. Marangoni, L. de A. Calderon, S. L. Da Silva
    Snake venom peptides and low mass proteins: Molecular tools and therapeutic agents
    Current Medicinal Chemistry, 23, ahead-of-print (2016).
    DOI: 10.2174/0929867323666161028155611

  111. A. Gomes, I. Fernandes, C. Teixeira, N. Mateus, M. J. Sottomayor, P. Gomes
    A quinacrine analogue selective against gastric cancer cells: insights from biochemical and biophysical studies
    ChemMedChem, 11, 2703-2712 (2016).
    DOI: 10.1002/cmdc.201600477

  112. M. Barbosa, N. Vale, F. M. T. A. Costa, M. C. L. Martins, P. Gomes
    Tethering antimicrobial peptides onto chitosan: optimization of azide-alkyne “click” reaction conditions
    Carbohydrate Polymers, 165, 384-393 (2017).
    DOI: 10.1016/j.carbpol.2017.02.050

  113. R. Ferrer-Gallego, J. M. Hernández-Hierro, N. F. Brás, N. Vale, P. Gomes, N. Mateus, V. de Freitas, F. J. Heredia, M. Teresa Escribano-Bailón
    Interaction between wine phenolic acids and salivary proteins by STD-NMR and molecular dynamics simulations.
    Journal of Agricultural and Food Chemistry, 65, 6434–6441 (2017).
    DOI: 10.1021/acs.jafc.6b05414

  114. S. Almeida Dias, J. M. Freire, C. Pérez-Peinado, M. M. Domingues, D. Gaspar, N. Vale, P. Gomes, D. Andreu, S. Troeira Henriques, M. Castanho, A. S. Veiga
    New potent membrane-targeting antibacterial peptides from viral capsid proteins.
    Frontiers in Microbiology: Antimicrobials, Resistance and Chemotherapy, 8: 775 (2017).
    DOI: 10.3389/fmicb.2017.00775

  115. N. Vale, A. Ferreira, I. Fernandes, C. Alves, M. J. Araújo, N. Mateus, P. Gomes
    Gemcitabine anti-proliferative activity significantly enhanced upon conjugation with cell-penetrating peptides.
    Bioorganic and Medicinal Chemistry Letters, 27, 2898-2901 (2017).
    DOI: 10.1016/j.bmcl.2017.04.086

  116. R. Ferraz, M. Pinheiro, C. Teixeira, A. Gomes, C. Prudêncio, S. Reis, P. Gomes
    Effects of novel triple-stage antimalarial ionic liquids on lipid membrane models.
    Bioorganic and Medicinal Chemistry Letters, 27, 4190-4193 (2017).
    DOI: 10.1016/j.bmcl.2017.07.006

  117. S. Galdiero, P. Gomes
    Peptide-Based Drugs and Drug Delivery Systems (editorial).
    Molecules, 22:2185 (2017).
    DOI: 10.3390/molecules22122185

  118. E. Moles, S. Galiano, A. Gomes, M. Quiliano, C. Teixeira, I. Aldana, P. Gomes, X. Fernández-Busquets
    ImmunoPEGliposomes for the targeted delivery of novel lipophilic drugs to red blood cells in a falciparum malaria murine model.
    Biomaterials, 145, 178-191 (2017).
    DOI: 10.1016/j.biomaterials.2017.08.020

  119. D. D. R. Arcanjo, A. G. Vasconcelos, L. A. Nascimento, A. C. Mafud, A. Plácido, M. M. M. Alves, C. Delerue-Matos, M. P. Bemquerer, N. Vale, P. Gomes, E. B. Oliveira, F. C. A. Lima, Y. P. Mascarenhas, F. A. A. Carvalho, U. Simonsen, R. M. Ramos, J. R. S. A. Leite
    Structure-function studies of BPP-BrachyNH2 and synthetic analogues thereof with Angiotensin I-Converting enzyme.
    European Journal of Medicinal Chemistry, 139, 401-411 (2017).
    DOI: 10.1016/j.ejmech.2017.08.019

  120. T. Silva, A. Moreira, K. Nazmi, T. Moniz, N. Vale, M. Rangel, P. Gomes, J. Bolscher, P. Rodrigues, M. Bastos, M. S. Gomes
    Lactoferricin peptides increase macrophage's capacity to kill Mycobacterium avium.
    mSphere, 2:e00301-17 (2017).
    DOI: 10.1128/mSphere.00301-17

  121. A. Gomes, C. Teixeira, R. Ferraz, C. Prudêncio, P. Gomes
    Wound-healing peptides for treatment of chronic diabetic foot ulcers and other infected skin injuries.
    Molecules, 22:1743 (2017).
    DOI: 10.3390/molecules22101743

  122. F. Costa, D. Sousa, M. Lamghari, P. Parreira, P. Gomes, C. Martins
    N-acetyl cysteine covalent immobilization prevents bacterial adhesion without impairing cellular adhesion and proliferation.
    Scientific Reports - Nature, 7, Article number: 17374 (2017).
    DOI: 10.1038/s41598-017-17310-4

  123. E. Barbosa, A. Oliveira, A. Plácido, R. Socodato, C. C. Portugal, A. C. Mafud, A. S. Ombredane, D. C. Moreira, N. Vale, L. J. Bessa, G. A. Joanitti, C. Alves, P. Gomes, C. Delerue-Matos, Y. P. Mascarenhas, M. M. Marani, J. B. Relvas, M. Pintado, J. Leite
    Structure and Function of a Novel Antioxidant Peptide from the Skin of Tropical Frogs.
    Free Radical Biology and Medicine, 115, 68-79 (2018).
    DOI: 10.1016/jfreeradbiomed.2017.11.001

  124. L. J. Bessa, P. Eaton, A. Dematei, A. Plácido, N. Vale, P. Gomes, C. Delerue-Matos, J. Leite, P. Gameiro
    Synergistic and antibiofilm properties of ocellatin peptides against multidrug-resistant Pseudomonas aeruginosa.
    Future Microbiology, 13, 151-163 (2018).
    DOI: 10.2217/fmb-2017-0175

  125. T. Silva, B. Claro, B. F. B. Silva, N. Vale, P. Gomes, M. S. Gomes, S. S. Funari, J. Teixeira, D. Uhríková, M. Bastos
    Unravelling a Mechanism of Action for a Cecropin A- Melittin Hybrid Antimicrobial Peptide: The Induced Formation of Multilamellar Lipid Stacks.
    Langmuir, 34, 2158-2170 (2018).
    DOI: 10.1021/acs.langmuir.7b03639

  126. J. Almeida, B. Mendes, M. Lancellotti, S. Marangoni, N. Vale, O. Passos, M. J. Ramos, P. Fernandes, P. Gomes, S. L. da Silva
    A novel synthetic peptide inspired on Lys49 phospholipase A2 from Crotalus oreganys abyssus snake venom active against multidrug-resistant clinical isolates.
    European Journal of Medicinal Chemistry, 149, 248-256 (2018).
    DOI: 10.1016/j.ejmech.2018.02.055

  127. A. Gomes, R. Ferraz, L. Ficker, M. S. Collins, C. Prudêncio, M. T. Cushion, C. A. S. Teixeira, P. Gomes
    Chloroquine analogues as leads against Pneumocystis lung pathogens.
    Antimicrobial Agents and Chemotherapy, 62, e00983-18 (2018).
    DOI: 10.1128/AAC.00983-18

  128. C. Morais, A. Cardoso, P. Cunha, L. Aguiar, N. Vale, E. Lage, M. Pinheiro, C. Nunes, P. Gomes, S. Reis, M. M. Castro, M. C. Pedroso de Lima, M. A. S. Jurado
    Acylation of the S413-PV cell-penetrating peptide as a means of enhancing its capacity to mediate nucleic acid delivery: relevance of peptide/lipid interactions.
    Biochimica et Biophysica Acta - Biomembranes, 1860, 2619-2634 (2018).
    DOI: 10.1016/j.bbamem.2018.10.002

  129. A. Mangoni, et al.
    Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes - 3 (editorial).
    Molecules, 23: 1596 (2018).
    DOI: 10.3390/molecules23071596

  130. J. Almeida, A. L. V. Palacios, R. S. P. Palma, B. Mendes, C. A. S. Teixeira, P. Gomes, S. L. da Silva
    Harnessing snake venom phospholipases A2 to novel approaches for overcoming antibiotic resistance.
    Drug Development Research, 80, 68-85 (2019).
    DOI: 10.1002/ddr.21456

  131. M. Barbosa, F. Costa, C. Monteiro, F. Duarte, M. C. L. Martins, P. Gomes
    Antimicrobial coatings prepared from Dhvar-5-click-grafted chitosan powders.
    Acta Biomaterialia, 84, 242-256 (2019).
    DOI: 10.1016/j.actbio.2018.12.001

  132. J. Durão, N. Vale, S. Gomes, P., P. Gomes, C. Barrias, L. Gales
    Nitric oxide release from antimicrobial peptide hydrogels for wound healing.
    Biomolecules, 9:4 (2019).
    DOI: 10.3390/biom9010004

  133. A. Mangoni, et al.
    Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes - 4 (editorial).
    Molecules, 24: 130 (2019).
    DOI: 10.3390/molecules24010130

  134. L. Aguiar, M. Machado, M. Sanches-Vaz, M. Prudêncio, N. Vale, P. Gomes
    Coupling the cell-penetrating peptides Transportan and Transportan 10 to primaquine enhances its activity against liver-stage malaria parasites.
    MedChemComm, 10, 221-226 (2019).
    DOI: 10.1039/C8MD00447A

  135. A. R. Dias, J. Costa-Rodrigues, C. Teixeira, P. Gomes, C. Prudêncio, R. Ferraz
    Ionic liquids for topical delivery in cancer.
    Current Medicinal Chemistry, 26, 7520-7532 (2019).
    DOI: 10.2174/0929867325666181026110227

  136. A. T. Silva, M. J. Cerqueira, C. Prudêncio, M. H. Fernandes, J. Costa-Rodrigues, C. Teixeira, P. Gomes, R. Ferraz
    Antiproliferative organic salts against cancer: disclosure of an ionic liquid selective against lung and liver cells.
    ACS Omega, 4, 5682-5689 (2019).
    DOI: 10.1021/acsomega.8b03691

  137. M. Fonte, N. Fagundes, A. Gomes, R. Ferraz, C. Prudêncio, M. J. Araújo, P. Gomes, C. Teixeira
    Development of a synthetic route towards N4,N9-disubstituted 4,9-diaminoacridines: on the way to multi-stage antimalarials.
    Tetrahedron Letters, 60, 1166-1169 (2019).
    DOI: 10.1016/j.tetlet.2019.03.052

  138. A. Mangoni, et al.
    Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes - 5 (editorial).
    Molecules, 24: 2415 (2019).
    DOI: 10.3390/molecules24132415

  139. C. S. M. Fernandes, A. S. Pina, A. J. M. Barbosa, I. Padrão, F. Duarte, C. Teixeira, V. Alves, P. Gomes, T. G. Fernandes, A. M. G. C. Dias, A. C. Roque
    Affinity-triggered assemblies based on a designed peptide-peptide affinity pair
    Biotechnology Journal, 14:1800559 (2019).
    DOI: 10.1002/biot.201800559

  140. C. Teixeira and P. Gomes
    The Xylella fastidiosa global threat: can antimicrobial peptides help in tackling this menace?
    Chimica Oggi - Chemistry Today, 37, 42-44 (2019).

  141. A. Gomes, L. J. Bessa, I. Fernandes, R. Ferraz, N. Mateus, P. Gameiro, C. Teixeira, and P. Gomes
    Turning a collagenesis-inducing peptide into a potent antibacterial and antibiofilm agent against multidrug-resistant Gram-negative bacteria.
    Frontiers in Microbiology, 10: 1915 (2019).
    DOI: 10.3389/fmicb.2019.01915

  142. B. Mendes, J. R. Almeida, N. Vale, P. Gomes, F. R. Gadelha, S. L. da Silva, D. Miguel
    Potential use of 13-mer peptides based on phospholipase and oligoarginine as leishmanicidal agents.
    Comparative Biochemistry and Physiology, Part C, 226: 108612 (2019).
    DOI: 10.1016/j.cbpc.2019.108612

  143. N. Mariz-Ponte, C. V. Correia, C. Teixeira, P. Gomes, C. Santos
    Doença do lenho do kiwi - esca, contexto e desafios.
    Agrotec, 33: 14-16 (2019).

  144. P. Parreira, C. Monteiro, V. Graça, J. Gomes, S. Maia, P. Gomes , I. C. Gonçalves, M. C. L. Martins
    Surface Grafted MSI-78A Antimicrobial Peptide has High Potential for Gastric Infection Management.
    Scientific Reports - Nature, 9: 18212 (2019).
    DOI: 10.1038/s41598-019-53918-4

  145. L. Aguiar, A. Biosca, E. Lantero, J. Gut, N. Vale, P. J. Rosenthal, F. Nogueira, D. Andreu, X. Fernández-Busquets, P. Gomes
    Coupling the Antimalarial Cell Penetrating Peptide TP10 to Classical Antimalarial Drugs Primaquine and Chloroquine Produces Strongly Hemolytic Conjugates.
    Molecules, 24:4559 (2019).
    DOI: 10.3390/molecules24244559

  146. A. T. Silva, C. M. Bento, A. C. Pena, L. M. Figueiredo, C. Prudêncio, L. Aguiar, T. Silva, R. Ferraz, M. S. Gomes, C. Teixeira, P. Gomes
    Cinnamic Acid Conjugates in the Rescuing and Repurposing of Classical Antimalarial Drugs.
    Molecules, 25:66 (2020).
    DOI: 10.3390/molecules2501066

  147. A. Mangoni, et al.
    Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes - 6 (editorial).
    Molecules, 25: 119 (2020).
    DOI: 10.3390/molecules25010119

  148. S. de Albuquerque, L. Cianni, D. de Vita, C. Duque, A. S. M. Gomes, P. Gomes, C. Laughton, A. Leitão, C. A. Montanari, R. Montanari, J. F. R. Ribeiro, J. S. da Silva, C. Teixeira
    Molecular Design Aided by Random Forests and Synthesis of Potent Trypanocidal Agents as Cruzain Inhibitors for Chagas Disease Treatment.
    Chemical Biology and Drug Design, 96, 948-960 (2020).
    DOI: 10.1111/cbdd.13663

  149. C. Teixeira, C. Ventura, J. R. B. Gomes, P. Gomes, F. Martins
    Cinnamic derivatives as antitubercular agents: characterization by quantitative structure-activity relationship studies.
    Molecules, 25:456 (2020).
    DOI: 10.3390/molecules25030456

  150. N. Vale, C. Alves, V. Sharma, D. F. Lázaro, S. Silva, P. Gomes, T. Fleming Outeiro
    A new MAP-Rasagiline conjugate reduces α-synuclein inclusion formation in a cell model.
    Pharmacological Reports, 72, 456–464 (2020).
    DOI: 10.1007/s43440-019-00032-x.pdf

  151. M. Gütschow, et al.
    Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes - 7 (editorial).
    Molecules, 25: 2968 (2020).
    DOI: 10.3390/molecules25132968

  152. C. Monteiro, H. Fernandes, D. Oliveira, N. Vale, M. Barbosa, P. Gomes, M. C. L. Martins
    AMP–Chitosan Coating with Bactericidal Activity in the Presence of Human Plasma Proteins.
    Molecules, 25: 3046 (2020).
    DOI: 10.3390/molecules25133046

  153. A. T. Silva, L. Lobo, I. S. Oliveira, J. Gomes, C. Teixeira, F. Nogueira, E. F. Marques, R. Ferraz, P. Gomes
    Building on Surface-Active Ionic Liquids for the Rescuing of the Antimalarial Drug Chloroquine.
    International Journal of Molecular Sciences, 21:5334 (2020).
    DOI: 10.3390/ijms21155334

  154. C. Morais, A. Cardoso, L. Aguiar, N. Vale, C. Nóbrega, M. Zuzarte, P. Gomes, M. C. Pedroso de Lima, A. S. Jurado
    Lauroylated histidine-enriched S413-PV peptide as an efficient gene silencing mediator in cancer cells.
    Pharmaceutical Research, 37:188 (2020).
    DOI: 10.1007/s11095-020-02904-x

  155. A. Gomes, L. J. Bessa, P. Correia, I. Fernandes, R. Ferraz, P. Gameiro, C. Teixeira, P. Gomes
    "Clicking" an ionic liquid to a potent antimicrobial peptide: on the route towards improved stability.
    International Journal of Molecular Sciences, 21:6174 (2020).
    DOI: 10.3390/ijms21176174

  156. B. M. Calisto, J. Ripoll-Rozada, L. J. Dowman, C. Franck, S. M. Agten, B. L. Parker, R. Carvalho Veloso, N. Vale, P. Gomes, D. de Sanctis, R. J. Payne, P. J. B. Pereira
    Sulfotyrosine-Mediated Recognition of Human Thrombin by a Tsetse Fly Anticoagulant Mimics Physiological Substrates.
    Cell Chemical Biology, 28, 26-33 (2021).
    DOI: 10.1016/j.chembiol.2020.10.002

  157. M. Fonte, N. Tassi, D. Fontinha, I. Bouzón-Arnáiz, R. Ferraz, M. J. Araújo, X. Fernández-Busquets, M. Prudêncio, P. Gomes, C. Teixeira
    4,9-diaminoacridines and 4-aminoacridines as dual-stage antiplasmodial hits.
    ChemMedChem, 16, 788-792 (2021).
    DOI: 10.1002.cmdc.202000740

  158. L. Aguiar, M. Pinheiro, A. R. Neves, N. Vale, S. Defaus, D. Andreu, S. Reis, P. Gomes
    Insights into the Membranolytic Activity of Antimalarial Drug-Cell Penetrating Peptide Conjugates.
    Membranes, 11:4 (2021).
    DOI: 10.3390/membranes11010004

  159. S. Silva, C. Alves, D. Duarte, A. Costa, B. Sarmento, A. J. Almeida, P. Gomes, N. Vale
    Model amphipathic peptide coupled with Tacrine to improve its antiproliferative activity.
    International Journal of Molecular Sciences, 22:242 (2021).
    DOI: 10.3390/ijms22010242

  160. A. R. Ferreira, C. Teixeira, C. F. Sousa, L. J. Bessa, P. Gomes, P. Gameiro
    How insertion of a single tryptophan in the N-terminus of a cecropin A-melittin hybrid peptide changes its antimicrobial and biophysical profile.
    Membranes, 11:48 (2021).
    DOI: 10.3390/membranes11010048

  161. M. Fonte, N. Tassi, P. Gomes, C. Teixeira
    Acridine-based antimalarials - from the very first synthetic antimalarial to recent developments.
    Molecules, 26:600 (2021).
    DOI: 10.3390/molecules26030600

  162. N. Mariz-Ponte, L. Regalado, E. Gimranov, N. Tassi, L. Moura, P. Gomes, F. Tavares, C. Santos, C. Teixeira
    A Synergic Potential of Antimicrobial Peptides against Pseudomonas syringae pv. actinidiae.
    Molecules, 26:1461 (2021).
    DOI: 10.3390/molecules26051461

  163. G. S. Oliveira, R. P. Costa, P. Gomes, M. S. Gomes, T. Silva, C. Teixeira
    Host defence peptides as potential anti-tubercular leads: a concise review.
    Pharmaceuticals, 14:323 (2021).
    DOI: 10.3390/ph14040323

  164. R. J. Mendes, L. Regalado, J. P. Luz, N. Tassi, C. Teixeira, P. Gomes, F. Tavares, C. Santos
    In vitro Evaluation of five antimicrobial peptides against the plant pathogen Erwinia amylovora.
    Biomolecules, 11:554 (2021).
    DOI: 10.3390/biom11040554

  165. A. T. Silva, C. Teixeira, E. F. Marques, C. Prudêncio, P. Gomes, R. Ferraz
    Surfing the third wave of ionic liquids: a brief review on the role of surface-active ionic liquids in drug development and delivery.
    ChemMedChem, 16, 2604-2611 (2021).
    DOI: 10.1002/cmdc.202100215

  166. A. A. Robles-Loaiza, E. A. Pinos-Tamayo, B. Mendes, C. Teixeira, C. Alves, P. Gomes, J. R. Almeida
    Peptides to tackle leishmaniasis: current status and future directions.
    International Journal of Molecular Sciences, 22:4400 (2021).
    DOI: 10.3390/ijms22094400

  167. M. da Silva, C. Teixeira, P. Gomes, M. Borges
    Promising Drug Targets and Compounds with Anti-Toxoplasma gondii Activity.
    Microorganisms, 9:1960 (2021).
    DOI: 10.3390/microorganisms9091960

  168. D. Fonseca, A. Moura, V. Leiro, R. Silva-Carvalho, B. N. Estevinho, C. L. Seabra, P. C. Henriques, M. Lucena, C. Teixeira, P. Gomes, P. Parreira, M. C. L. Martins
    Grafting MSI-78A onto chitosan microspheres enhances its antimicrobial activity.
    Acta Biomaterialia, 137, 186-198 (2022).
    DOI: 10.1016/j.actbio.2021.09.063

  169. P. Alves, C. Barrias, P. Gomes, M. C. L. Martins
    Smart biomaterial-based systems for intrinsic stimuli-responsive chronic wound management.
    Materials Today Chemistry, 22:100623 (2021).
    DOI: 10.1016/j.mtchem.2021.100623

  170. E. A. Barbosa et al.
    The peptide secreted at the water to land transition in a model amphibian has antioxidant effects.
    Proceedings of the Royal Society B: Biological Sciences, 288:20211531 (2021).
    DOI: 10.1098/rspb.2021.1531

  171. A. Gomes, L. Aguiar, R. Ferraz, C. Teixeira, P. Gomes
    The emerging role of ionic liquid-based approaches for enhanced skin permeation of bioactive molecules: a snapshot of the past couple of years.
    International Journal of Molecular Sciences, 22:11991 (2021).
    DOI: 10.3390/ijms222111991

  172. B. Costa, G. Martínez-de-Tejada, P. Gomes, M. C. L. Martins, F. Costa
    Antimicrobial peptides in the battle against orthopedic implant-related infections – a review.
    Pharmaceutics, 13:1918 (2021).
    DOI: 10.3390/pharmaceutics13111918

  173. A. Gomes, L. J. Bessa, I. Fernandes, R. Ferraz, C. Monteiro, M. C. L. Martins, N. Mateus, P. Gameiro, C. Teixeira, P. Gomes
    Disclosure of a Promising Lead to Tackle Complicated Skin and Skin Structure Infections: Antimicrobial and Antibiofilm Actions of Peptide PP4-3.1.
    Pharmaceutics, 13:1962 (2021).
    DOI: 10.3390/pharmaceutics13111962

  174. R. J. Mendes, S. Sario, J. P. Luz, N. Tassi, C. Teixeira, P. Gomes, F. Tavares, C. Santos
    Evaluation of three peptides mixtures to control the phytopathogen responsible for fire blight disease.
    Plants, 10:2367 (2021).
    DOI: 10.3390/plants10122637

  175. A. T. Silva, I. S. Oliveira, J. Gomes, L. Aguiar, D. Fontinha, D. Duarte, F. Nogueira, M. Prudêncio, E. F. Marques, C. Teixeira, R. Ferraz, P. Gomes Drug-derived surface-active ionic liquids: a cost-effective way to expressively increase blood-stage antimalarial activity of primaquine.
    ChemMedChem, 17:e202100650 (2022).
    DOI: 10.1002/cmdc.202100650

  176. J. R. Almeida, B. Mendes, M. Lancellotti, G. Franchi, O. Passos, M. J. Ramos, P. A. Fernandes, C. Alves, N. Vale, P. Gomes, S. L. da Silva
    Lessons from a single natural amino acid substitution: anticancer and antibacterial properties of two phospholipase A2-derived peptides.
    Current Issues in Molecular Biology, 44, 46-62 (2022).
    DOI: 10.3390/cimb44010004

  177. A. A. Robles-Loaiza, E. A. Pinos-Tamayo, B. Mendes, J. A. Ortega-Pila, C. Proaño-Bolaños, F. Plisson, C. Teixeira, P. Gomes, J. R. Almeida
    Traditional and Computational Screening of Non-Toxic Peptides and Approaches to Improving Selectivity.
    Pharmaceuticals, 15:323 (2022).
    DOI: 10.3390/ph15030323

  178. A. Plácido et al.
    Neuroprotective effects on microglia and insights into the structure-activity relationship of an antioxidant peptide isolated from Pelophylax perezi.
    Journal of Cellular and Molecular Medicine, 26, 2793-2807 (2022).
    DOI: 10.1111/jcmm.17292

  179. P. Alves et al.
    Thiol-norbornene Photoclick Chemistry for Grafting Antimicrobial Peptides onto Chitosan to Create Antibacterial Biomaterials.
    ACS Applied Polymer Materials, 4, 5012-5026 (2022).
    DOI: 10.1021/acsapm.2c00563

  180. A. Gomes et al.
    Boosting Cosmeceutical Peptides: Coupling Imidazolium-Based Ionic Liquids to Pentapeptide-4 Originates New Leads with Antimicrobial and Collagenesis-Inducing Activities.
    Microbiology Spectrum, 10(4), e02291-21 (2022).
    DOI: 10.1128/spectrum.02291-21

  181. A. M. Ramôa et al.
    Antimicrobial peptide-grafted PLGA-PEG Nanoparticles to Fight Bacterial Wound Infections.
    Biomaterials Science, 11, 499-508 (2023).
    DOI: 10.1039/D2BM01127A

  182. C. M. Bento, et al.
    Improving the antimycobacterial drug clofazimine through formation of organic salts by combination with fluoroquinolones.
    International Journal of Molecular Sciences, 24(2), 1402 (2023).
    DOI: 10.3390/ijms24021402

  183. A. R. Ferreira, et al.
    The unusual aggregation and fusion activity of the antimicrobial peptide W-BP100 in anionic vesicles.
    Membranes, 13(2), 138 (2023).
    DOI: 10.3390/membranes13020138

  184. J. R. de Almeida, et al.
    Unlocking the potential of snake venom-based molecules against the malaria, Chagas disease, and leishmaniasis triad.
    International Journal of Biological Macromolecules, 242, 124745 (2023).
    DOI: 10.1016/j.ijbiomac.2023.124745

  185. M. Barbosa, et al.
    Influence of immobilization strategies on the antibacterial properties of antimicrobial peptide-chitosan coatings.
    Pharmaceutics, 15, 1510 (2023).
    DOI: 10.3390/pharmaceutics15051510

  186. L. Regalado, et al.
    Towards a sustainable management of the spotted-wing drosophila: disclosing the effects of two spider venom peptides on Drosophila suzukii.
    Insects, 14:533 (2023).
    DOI: 10.3390/insects14060533

  187. M. Fonte, et al.
    New 4-(N-cinnamoylbutyl)aminoacridines as potential multi-stage antiplasmodial leads.
    European Journal of Medicinal Chemistry, 258:115575 (2023).
    DOI: 10.1016/j.ejmech.2023.115575

  188. L. Pereira-Dias, et al.
    Peptaibiotics: harnessing the potential of microbial secondary metabolites for mitigation of plant pathogens.
    Biotechnology Advances, 68:108223 (2023).
    DOI: 10.1016/j.biotechadv.2023.108223


  189. P. M. Alves, et al.
    Norbornene-chitosan nanoparticles with and without a conjugated VEGF-peptide analog to promote vascularization.
    Materials Chemistry Today, 36:101942 (2024).
    DOI: 10.1016/j.mtchem.2024.101942


  190. M. Fonte, et al.
    Improved synthesis of antiplasmodial 4-aminoacridines and 4,9-diaminoacridines.
    RSC Advances, 14, 6253-6261 (2024).
    DOI: 10.1039/d4ra00091a

  191. M. Fonte, et al.
    Disclosure of cinnamic acid/4,9-diaminoacridine conjugates as multi-stage antiplasmodial hits.
    Bioorganic & Medicinal Chemistry, 104:117714 (2024).
    DOI: 10.1016/j.bmc.2024.117714


  192. D. Fonseca, et al.
    One-pot microfluidics to engineer chitosan nanoparticles conjugated with antimicrobial peptides using “photoclick” chemistry: validation using the gastric bacterium Helicobacter pylori.
    ACS Applied Materials & Interfaces, 16, 14533–14547 (2024).
    DOI: 10.1021/acsami.3c18772


  193. P. M. Alves, et al.
    How can biomaterial-conjugated antimicrobial peptides fight bacteria and be protected from degradation?
    Acta Biomaterialia, 181, 98-116 (2024).
    DOI: 10.1016/j.actbio.2024.04.043

  194. A. T. Silva, et al.
    “Seasoning” antimalarial drugs’ action: chloroquine bile salts as novel triple-stage antiplasmodial hits.
    (featured in the journal's front cover)
    RSC Med Chem, 15, 2657-2662 (2024).
    DOI: 10.1039/D4MD00007B

  195. N. L. Cancelarich, et al.
    First Bioprospecting Study of Skin Host-Defense Peptides in Odontophrynus americanus.
    Journal of Natural Products, ahead-of-print (2024).
    DOI: 10.1021/acs.jnatprod.4c00184

  196. B. Costa, et al.
    Dhvar5-Chitosan Nanogels and their Potential to Improve Antibiotics Activity.
    International Journal of Biological Macromolecules, 277, 134059 (2024).
    DOI: 10.1016/j.ijbiomac.2024.134059

  197. M. Fonte, et al.
    Repurposing antiplasmodial leads for cancer: exploring the antiproliferative effects of N-cinnamoyl-aminoacridines.
    Bioorganic & Medicinal Chemistry Letters, 111, 129894 (2024).
    DOI: 10.1016/j.bmcl.2024.129894

  198. A. T. Silva, et al.
    High Efficacy of Chloroquine-derived Bile Salts in Pluronic F127 Micelles Against Blood-Stage Plasmodium falciparum.
    Journal of Molecular Liquids, 413, 125986 (2024).
    DOI: 10.1016/j.molliq.2024.125986

  199. S. Silva, et al.
    Bioprospecting a natural antioxidant peptide for tomato biostimulation under water limitations: physiological approach.
    Journal of Plant Growth Regulation, accepted (2024).
    DOI: -

[1] Now "Chemical Biology & Drug Design" (Print ISSN: 1747-0277; Online ISSN: 1747-0285).